Scale-up of High-Shear Mixer Granulators

Scale-up studies on high shear wet granulation process from mini-scale to commercial scale.

A newly developed mini-scale high shear granulator was used for scale-up study of wet granulation process from 0.2 to 200 L scales. Under various operation conditions and granulation bowl sizes, powder mixture composed of anhydrous caffeine, D-mannitol, dibasic calcium phosphate, pregelatinized starch and corn starch was granulated by adding water. The granules were tabletted, and disintegratio...

Production Scale Up of Nanofibers: A Review

Investigation of Effective Parameters on Phase Inversion Hold-up in Continuous Mixer-settler

In this paper, we studied effect of different parameters including density, viscosity, interfacial tension and solute transfer concentration on phase inversion hold-up. The results showed that change in phase density ratio had no effect on phase inversion hold-up. It also disclosed that the phase viscosity ratio was the most effective parameter affecting phase inversion hold-up and each phase h...

Design of a 2.4 GHz High-Performance Up-Conversion Mixer with Current Mirror Topology

In this paper, a low voltage low power up-conversion mixer, designed in a Chartered 0.18 μm RFCMOS technology, is proposed to realize the transmitter front-end in the frequency band of 2.4 GHz. The up-conversion mixer uses the current mirror topology and current-bleeding technique in both the driver and switching stages with a simple degeneration resistor. The proposed mixer converts an input o...

Optimization of operating conditions in a high-shear mixer using dem model: determination of optimal fill level.

For the purpose of evaluating optimal fill level of starting materials in a high-shear mixer, discrete element method (DEM) simulation was conducted to visualize kinetic status between particles. The simulation results obtained by changing fill levels were used to determine solid fraction of particles, particle velocity, particle velocity vector, and kinetic energy and discuss the flow pattern....